Antigenic differences between the EG95-related proteins from Echinococcus granulosus G1 and G6 genotypes: Implications for vaccination

CA Alvarez Rojas; CG Gauci; MW Lightowlers

Journal article

Antigenic differences between the EG95-related proteins from Echinococcus granulosus G1 and G6 genotypes: Implications for vaccination

CA Alvarez Rojas, CG Gauci, MW Lightowlers

Parasite Immunology | Published : 2013

DOI: 10.1111/pim.12009

Abstract

Cystic echinococcosis caused by Echinococcus granulosus remains an important and neglected issue in public health. The study of the likely efficacy of the currently available EG95 vaccine against other genotypes of the parasite is important to improve the vaccine as a potential tool to be used in control programmes. The recombinant vaccine EG95-1G1 was developed based on the G1 genotype of E. granulosus. Characterization of the eg95 gene family in the G6 genotype by genomic DNA cloning previously produced the first unequivocal information about the composition of the gene family in a different genotype. The information was used in this study to predict and express two EG95-related proteins f..

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University of Melbourne Researchers

Charles Gauci Author

Marshall Lightowlers Author

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Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

Cristian A. Alvarez Rojas is a recipient of a MRS and MIRFS scholarships from The University of Melbourne. Funding is acknowledged from the Australian National Health and Medical Research Council, grant numbers 350279, 628320, 100354.